Drug Uses

Flexeril is a muscle relaxant, used to treat the pain and stiffness of muscle injuries, including strains, sprains and muscle spasms. The active ingredient in Flexeril is cyclobenzaprine.

How Taken

Flexeril comes in 10 mg tablets, and the normal dose in adults is one 10 mg tablet three times daily. You should not exceed a total dosage of 60 mg of Flexeril per day. It might be taken with food if stomach upset occurs. Take Flexeril as directed. Do not increase your dose or take it more often than prescribed.

Warnings/Precautions

Flexeril may not be suitable for all individuals. If you have had any of the following conditions in the past, or are being treated for them now, please inform your doctor. In some cases side effects may be minimized by following your doctor's advice, but you may be advised not to take Flexeril. Before taking this drug, tell your doctor if you have: glaucoma, an overactive thyroid gland, heart disease, difficulty urinating or any allergies. Inform your doctor if you are pregnant or breast-feeding before taking this drug.

Missed Dose

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Possible Side Effects

May cause stomach upset, heartburn, constipation, headache, dizziness or drowsiness or dry mouth the first few days as your body adjusts to the medication. If these symptoms persist or become severe, notify your doctor. Inform your doctor if you develop: muscle stiffness, skin rash, itching, rapid heart rate, swelling of the face, difficulty urinating. When rising quickly from a sitting or lying position, dizziness or lightheadedness may occur. Change positions slowly and use caution on stairs. Avoid activities requiring alertness if dizziness or drowsiness occurs. If you notice other effects not listed above, contact your doctor or pharmacist.

Storage

Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) and out of reach of children.

Overdose

The following symptoms indicate an overdose, get medical help immediately: difficulty breathing, extreme nervousness or restlessness, flushed skin, hallucination, racing or irregular heartbeat, seizure, shortness of breath, tiredness (extreme), unstable temperature, unusual muscle stiffness, vomiting (in combination with these other symptoms).

More Information

Flexeril may enhance the effects of alcohol, barbiturates, and other CNS depressants.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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General considerations in the use of muscle relaxants
Muscle relaxants are principally used to provide good muscular relaxation for surgery. When they are used respiration must be controlled via an endotracheal tube. A few general guidelines for the use of relaxants are listed below:
1. Always be certain that you will able to ventilate the patient by face mask before paralysing them.
2. If a rapid onset of action is required then suxamethonium should be used as it acts more quickly than any of the non-depolarising drugs. If a short duration of paralysis is required suxamethonium is most suitable and may be given in repeated doses provided atropine is administered prior to the second dose of suxamethonium to avoid bradycardia.
3. Non-depolarising muscle relaxants take about one and a half to two minutes to act and you should allow time for relaxation to develop before attempting intubation.
4. The supplemental dose should be about 25% of the initial dose. Never attempt to reverse the relaxation until at least 15-20 minutes after the last dose of relaxant was given.
5. Never extubate a patient until you are certain that the paralysis has been reversed and they have adequate muscle strength to protect their airway and breathe. One way of testing this is to assess whether they are able to lift their head off the pillow for 5 seconds. Ensure that breathing is of adequate depth and frequency.
6. It takes some time before the larynx is able to protect the airway and so the patient is best placed in the lateral position for recovery.
7. If a nerve stimulator is available it can be used to monitor the degree of relaxation. However it is not essential and relaxants can be safely be used without a nerve stimulator by careful observation of clinical signs.
8. When muscle relxants are administered awareness is always a danger since a paralysed patient cannot move in response to pain. It is therefore essential to ensure that the depth of anaesthesia is adequate.

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