Drug Uses

Effexor XR is a potent inhibitor of the reuptake of serotonin and norepinephrine-two neurotransmitters thought to play important roles in the pathophysiology of depression. Correcting the imbalance of these two chemicals may help relieve symptoms of depression.

How Taken

Effexor XR comes as a capsule to take by mouth. It is usually taken once a day and should be taken with food. Each capsule should be swallowed whole with fluid and not divided, crushed, chewed, or placed in water, or it may be administered by carefully opening the capsule and sprinkling the entire contents on a spoonful of applesauce. This drug/food mixture should be swallowed immediately without chewing and followed with a glass of water to ensure complete swallowing of the pellets.

Warnings/Precautions

Before starting Effexor XR, tell your doctor about any medicines you're taking, including over-the-counter drugs and herbal supplements. If you take MAOIs you should not take Effexor XR. If you are taking antidepressants you should be watched closely for signs that your condition is getting worse or that you are becoming suicidal, especially when you first start therapy, or when your dose is increased or decreased. You should also be watched for becoming agitated, irritable, hostile, impulsive, or restless. Such symptoms should be reported to your doctor right away. Effexor XR may raise blood pressure in some patients, so blood pressure should be monitored regularly. When you suddenly stop using or quickly lower your daily dose of Effexor XR, discontinuation symptoms may occur. Talk to your doctor before discontinuing or reducing your dose of Effexor XR. Pregnant or nursing women shouldn't take any antidepressant without consulting their doctor. Until you see how Effexor XR affects you, be careful doing such activities as driving a car or operating machinery. Avoid drinking alcohol while taking Effexor XR.

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next one as directed. Do not take a double dose of this medication.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Effexor XR and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); seizures; or an irregular heartbeat or severely high blood pressure (blurred vision, headache). Other, less serious side effects may be more likely to occur. Continue to take Effexor XR and talk to your doctor if you experience nausea, vomiting, upset stomach, abdominal pain, or loss of appetite or weight; dry mouth; drowsiness or dizziness; mild tremor, anxiety, or agitation; insomnia; abnormal dreams; sexual problems such as impotence, abnormal ejaculation, difficulty reaching orgasm, or decreased libido; sweating; yawning; or increase in blood cholesterol levels (detected by blood tests); Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store Effexor XR at room temperature (68F to 77F or 20C to 25C). Keep Effexor XR away from children.

Overdose

Seek emergency medical attention if an overdose is suspected. Symptoms of an Effexor XR overdose may include dizziness, drowsiness, numbness, nausea, irregular heartbeats, seizures, and unconsciousness.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Effexor XR may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness, dizziness, and confusion Do not stop taking Effexor XR without first talking to your doctor. Your doctor may need to gradually reduce the dose before stopping the medication completely. Stopping the medication suddenly may cause unpleasant side effects to occur.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Most of the Americans pay more for essential prescription medicines than the neighboring countries like Canada. And adding to this is the aggressive pricing policies of American pharmacy companies. The prices remain to continue to rise in the US, while they remain much less expensive in other countries. This disparity in prices has led to a rise in the popularity of Effexor Xr.These discount pharmacies sell branded as well as exact generic equivalents of US FDA approved prescription drugs at a discounted rate, some even claiming to a saving of 70% off retail prices as they order in bulk.


Q: What is your cancellation policy for Effexor Xr?
A: You may cancel your order before the order has shipped or been approved by the doctor. If the order has already been shipped or approved we cannot cancel your order. Please refer to the current cancellation policy in the terms & conditions section of our order page for more information.


Second-generation Antidepressants
A recent article in the prestigious British Medical Journal seems to confirm an increased risk for suicidal behavior among adults taking popular antidepressants. This follows evidence that certain selective serotonin reuptake inhibitors (SSRIs) may have a similar effect among children and adolescents.
As with the controversy over certain painkillers, public policy about the use of Prozac, Paxil, Zoloft and other antidepressants must balance the known benefits with the newly emerging risks. This month's Facts of Life takes an evidence-based second look at second-generation antidepressants.
Their names-Prozac, Paxil, Zoloft-are familiar ones in a country where about one in five people suffer from depression or similar mental disorders. These so-called "second-generation" antidepressant medications have been the treatment of choice since 1985.
Coming In Second
Second-generation antidepressants include selective serotonin reuptake inhibitors (SSRIs) and other similar drugs that work primarily by increasing the amount of time that the hormone serotonin circulates in the connective gap between nerve cells in the brain. Serotonin helps nerve cells communicate with one another, communication that often lags in depressed brains.
SSRIs like Prozac are called second-generation because they are now prescribed more often than earlier-introduced "first generation" tricyclic antidepressants. Tricyclic drugs work in a similar way to SSRIs, but they are toxic at smaller doses and tend to have more serious side effects.
Taking Stock
The new antidepressants are a success story, an effective treatment for millions and a market winner for many drug companies. But researchers are just beginning to examine the 20 years' worth of data available for the drugs to answer some pressing questions about their use. Are all second-generation antidepressants equally effective? How often do serious side effects like suicide occur? And should the medications be used sparingly in certain groups, like children and pregnant women?. A review of the cost effectiveness of depression treatment concluded that there are few studies that compare the cost-effectiveness of behavioral and drug-based therapies for depression.1
The Facts:
* Approximately one in five Americans has a mental disorder such as depression, anxiety disorder, bipolar disorder or a similar condition that can be treated with second-generation antidepressant drugs.
* A 2004 meta-analysis of antidepressant medications, including seven SSRI drugs, concluded that the medications had a "modest beneficial effect" on patients with combined depression and substance abuse disorders.
* A new systematic review of studies including 87,650 patients found a twofold increase in suicide attempt rates in SSRI patients compared to those taking a placebo or other therapies than tricyclic antidepressants.
* Second-generation antidepressants may be preferred over older tricyclic drugs as a first line treatment for bipolar depression, according to a 2004 systematic review.
* Most studies of antidepressant treatment for people age 55 and older exclude patients with other serious health problems, making it difficult to conduct medication trials with a large number of study participants.
* Rates of stroke and brain hemorrhage in patients taking SSRI drugs are very low, despite the fact that serotonin can affect blood clotting and blood vessel diameter in the brain.
* The Center for Science in the Public Interest's review of studies on SSRI treatment for children found that industry-funded studies are 50 percent more likely to report positive treatment outcomes than government or university-funded studies.
* A systematic review of unpublished research on SSRI treatments for adolescents suggest that many SSRIs, with exception of Prozac, are more risky to the health of teens than published data would suggest.
* A meta-analysis of studies of antidepressant treatment for obsessive-compulsive disorder in children found that the older tricyclic antidepressant clomapramine (Anafranil) was significantly more effective in treating the disorder than four SSRI drugs.
* The "best buys" in second-generation antidepressants, based on safety, effectiveness and cost, are generic fluoxetine (Prozac and Sarafem), citalopram (Celexa) and buproprion (Wellbutrin), according to a 2005 Consumers Union report.
Catching the Problem Early:
In November 2004, the Center for Evidence-based Policy at the Oregon Health and Science University released a report on the effectiveness of "second-generation" antidepressant medications. 12 The report included information on how well Prozac, Wellbutrin, Zoloft, Celexa and similar drugs worked for conditions like major depression, social anxiety disorder, obsessive compulsive disorder and premenstrual disorders. But the report's authors had a more unusual and potentially controversial goal in mind for their work: which one of these drugs worked the best, in head-to-head competition with the others?
For consumers and physicians alike, their findings might be a little unnerving. Report author Richard Hansen, Ph.D., says the evidence is "fair to good" that these second-generation antidepressants "do not differ substantially" among themselves and seem to be equally effective and tolerable.
Hansen, a researcher at the University of North Carolina at Chapel Hill, and colleagues found some small differences in how fast the drugs worked and in the prevalence of certain side effects like sleep disturbances and sexual dysfunction. Most of the few head-to-head studies they analyzed looked at treatment for depression. "For most [other] indications, no head-to-head trials have been conducted," Hansen says.
Few of the studies analyzed in the report looked at how well the drugs performed in different racial and ethnic groups and special populations like children and older adults, Hansen and colleagues found.
" Oftentimes companies do not look at subpopulations," says John Santa, M.D., of the Center for Evidence-based Policy. "It's too expensive, ethically risky in children, and let's face it-once the FDA approves the drug (the pharmaceutical companies) can figure out ways to present information regarding various issues to patients and doctors without going through the FDA,"
Santa's group, which reviews the effectiveness of drugs from beta-blockers to Alzheimer's disease medications, commissioned the study of antidepressants in part "because antidepressants represent the second largest drug class for Medicaid drug dollars." Increasing availability of generic versions of the drugs, along with new concerns about higher suicide rates in SSRI users, prompted the review, Santa says.
For the most part, the FDA does not require head-to-head effectiveness comparisons of drugs within a class as part of its determination of whether a new medication should be approved. Without this crucial data, Santa says, drug companies can make claims for their products that justify higher and higher prices.
As systematic reviews like the Oregon report conclude there are few differences between drugs within a class, "it's much more likely that (drug) manufacturers will also have to compete on the basis of price," according to Santa.

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