Drug Uses

Amoxil is an antibiotic in the class of drugs called penicillin. It fights bacteria in the body. Amoxil is used to treat many different types of infections, such as tonsillitis, pneumonia, ear infections, bronchitis, urinary tract infections, gonorrhea, and infections of the skin. Amoxil may also be used for other purposes.

How Taken

Amoxil comes as a capsule, chewable tablet, liquid, and pediatric drop to take by mouth. It is usually taken every 8 hours (three times a day). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Amoxil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid and pediatric drops well before each use to mix the medication evenly. Use the bottle dropper to measure the dose of pediatric drops. The pediatric drops and liquid may be placed on a child's tongue or added to formula, milk, fruit juice, water, ginger ale, or other cold liquid and taken immediately. The tablets should be crushed or chewed thoroughly before they are swallowed. The capsules should be swallowed whole and taken with a full glass of water. Continue to take Amoxil even if you feel well. Do not stop taking Amoxil without talking to your doctor.

Warnings/Precautions

If you have ever had an allergic reaction to another penicillin or to a cephalosporin, do not take Amoxil without first talking to your doctor. Before taking Amoxil, tell your doctor if you have kidney disease, or stomach or intestinal disease. Amoxil is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Amoxil is generally considered to be safe for use during pregnancy. Do not, however, take Amoxil without first talking to your doctor if you are pregnant or could become pregnant during treatment. Amoxil passes into breast milk. Although serious problems have not been reported, rarely, Amoxil may cause a yeast infection, diarrhea, or an allergic reaction in a nursing infant, although no serious harm is expected. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

Take the missed dose as soon as you remember, and take the rest of the day's doses at evenly spaced intervals. However, if it is almost time for the next regularly scheduled dose, skip the dose you missed and take the rest of the doses for the day as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

Possible Side Effects

Contact your doctor immediately if you experience severe or bloody diarrhea and abdominal cramps during treatment with Amoxil. If you experience any of the following serious side effects, stop taking Amoxil and seek emergency medical attention or contact your doctor immediately: an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting); seizures; or unusual bleeding or bruising. Other, less serious side effects may be more likely to occur. Continue to take Amoxil and talk to your doctor if you experience mild nausea, vomiting, diarrhea, or abdominal pain, white patches on the tongue (thrush/ yeast infection); itching or discharge of the vagina (vaginal yeast infection); black, "hairy" tongue or sore mouth or tongue. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Keep out of the reach of children. Store away from heat and direct light. Do not store the capsule or tablet form of Amoxil in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down. Store the oral liquid form of Amoxil in the refrigerator because heat will cause this medicine to break down. However, keep the medicine from freezing. Follow the directions on the label. Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Overdose

Symptoms of an Amoxil overdose may include muscle spasms or weakness, pain or twitching, pain in the fingers or toes, loss of feeling in the fingers or toes, seizures, confusion, coma, or agitation. Seek emergency medical attention if an overdose is suspected.

More Information

Contact your doctor immediately if you experience severe or bloody diarrhea and abdominal cramps during treatment with Amoxil. Take all of the Amoxil that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated. Amoxil may decrease the effectiveness of birth control pills. If you are taking birth control pills, use a second method of birth control while taking Amoxil to ensure protection from unintended pregnancy.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Antibiotics Prescribed for Sinus Infections
The use of antibiotics for acute and chronic rhinosinusitis far outweighs the predicted prevalence of bacterial causes of these conditions, reported Hadley Sharp, B.S., and Donald Leopold, M.D., of the University of Nebraska here, and colleagues, in the March issue of the Archives of Otolaryngology -- Head and Neck Surgery.
Given the concern about antibiotic resistance and increasingly virulent bacteria, when two-thirds of patients with sinus symptoms expect or receive an antibiotic, these disorders hold special pertinence.
The researchers used data for 1999 to 2002 from two national surveys (the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey) conducted by the National Center for Health Statistics.
They found that an estimated 14,277,026 visits were made to health care facilities for chronic rhinosinusitis (symptoms lasting 12 or more weeks) and 3,116,142 for acute infections (symptoms up to four weeks). In 2002, rhinosinusitis accounted for 21% of all antibiotic prescriptions for adults and 9% for children.
At least one antibiotic was prescribed at 82.74% of visits for an acute infection, and at 69.95% of visits for a chronic infection in which inflammation is actually the most likely cause, the investigators reported.
After antibiotics, the drugs most used were antihistamines, nasal decongestants, corticosteroids, and antitussive, expectorant, and mucolytic agents, the authors wrote.
Furthermore, despite contradictory efficacies reported in the literature, inhaled or nasal corticosteroids were used in 15.05% of visits for acute cases, a rate more often than published studies imply is necessary, the researchers said. The use of corticosteroids although "not rare" in this setting, is of "undetermined benefit," they noted.
Within the class of antibiotics, penicillins, mainly amoxicillin and amoxicillin-clavulanate potassium (Augmentin), were appropriately the most commonly used medication class for both chronic and acute bacterial sinusitis, the investigators said. A penicillin drug was mentioned in 30.35% of all visits for chronic infection and in 27.18% of visits for acute infection.
Questionable, the researchers said, is the frequent use of the antibiotic class that included erythromycins, lincosamides, and macrolides, as well as other classes having higher antimicrobial efficacy.
The use of these drugs in 24.32% of acute visits put these antibiotics ahead of cephalosporins, sulfonamides and trimethprim, and tetracyclines, in that order, the researchers said.
An area where the findings fit nicely with current recommendations, the researchers said, is the use of antihistamines, which roughly matched the 20% U.S. prevalence of their major indication, allergic rhinosinusitis. The use of antihistamines (20.93% of visits for chronic sinusitis and 25.26% for acute cases) seemed logical, they said.
In discussing the complexity of acute and chronic rhinosinusitis, the researchers noted that it is understandable why the approach to treatment remains controversial.
Inasmuch as viruses are often involved in the acute form, many advocate no treatment if the symptoms are not severe, wane in five to seven days, and resolve in 10 days. There are guidelines for treatment of the acute forms and especially for acute bacterial rhinosinusitis. However, chronic disorders are more complex, they said.
A limitation of this study is that the use of over-the-counter medicines or home remedies was not recorded. The use of hot packs or physician-recommended irrigation with saline solution may have been used as often as an antihistamine prescription.
The vast use of antibiotics suggests that they seem to be effective or they would have been abandoned, the researchers said. However, they added, another possibility is that many patients have self-limited disease, while their physicians prescribe what they think will work. In time, however, may infections resolve regardless of treatment.
"To attribute efficacy or curative credit to a drug class based solely on resolution of symptoms without comparison with nontreated control subject, physicians could be oversatisifed with their own prescribing habits," the investigators concluded.

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